You may not put any player(s) on IR prior to the season. If one of your keeper player gets injured (season-ending IR) during training camp, in order to keep that player, you must still draft him.
Prior to the live online draft, you can still submit an alternate keeper in place of your IR player but you will then loose all rights to that prior keeper that got injured. Once you release the IR player, he becomes a FA and another team will be able to draft that IR player.
For example: If a team submits Matt Forte as one of their 5 keepers, and Forte gets injured in pre-season, in order to hold the rights to this player, the team must still draft him as their keeper. If the team decides to release Forte as one of their keepers, the team can submit another alternate keeper player but Forte will now become a FA. Any other team will be able to draft Matt Forte during the draft.